Zosaar HCT Dosage/Direction for Use

Zosaar HCT may be administered with other antihypertensive agents.
Zosaar HCT may be administered with or without food.
Fixed-dose combination is not indicated for initial therapy.
Hypertension: The usual starting and maintenance dose of Zosaar HCT is 1 tab of Zosaar HCT 50/12.5 (losartan potassium 50 mg/hydrochlorothiazide 12.5 mg) once daily. For patients who do not respond adequately to Zosaar HCT 50/12.5, the dosage may be increased to 1 tab of losartan potassium 100 mg/hydrochlorothiazide 25 mg once daily or 2 tabs of Zosaar HCT 50/12.5 once daily. The maximum dose is 1 tab of losartan potassium 100 mg/hydrochlorothiazide 25 mg once daily or 2 tabs of Zosaar HCT 50/12.5 once daily. In general, the antihypertensive effect is attained within 3 weeks after initiation of therapy. Losartan potassium 100 mg/hydrochlorothiazide 12.5 mg is available for those patients titrated to 100 mg of Losartan who require additional blood pressure control.
Zosaar HCT should not be initiated in patients who are intravascularly volume-depleted (eg, those treated with high-dose diuretics).
Zosaar HCT is not recommended for patients with severe renal impairment (creatinine clearance ≤30 mL/min) or for patients with hepatic impairment.
No initial dosage adjustment of Zosaar HCT is necessary for elderly patients. Losartan potassium 100 mg/hydrochlorothiazide 25 mg should not be used as initial therapy in elderly patients.
Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is losartan 50 mg once daily. If goal blood pressure is not reached with losartan 50 mg, therapy should be titrated using a combination of losartan and a low dose of hydrochlorothiazide (12.5 mg) and, if needed, the dose should then be increased to losartan 100 mg and hydrochlorothiazide 12.5 mg once daily. If necessary, the dose should be increased to losartan 100 mg and hydrochlorothiazide 25 mg once daily. Zosaar HCT 50/12.5, Losartan potassium 100 mg/hydrochlorothiazide 12.5 mg and losartan potassium 100 mg/hydrochlorothiazide 25 mg are suitable alternative formulations in patients who would otherwise be treated concomitantly with losartan plus hydrochlorothiazide.